Fans play an irreplaceable role in environmental protection in the pharmaceutical manufacturing industry. Their high cleanliness and precise control characteristics directly affect the quality of pharmaceuticals. In GMP clean workshops, the laminar flow fan filtration unit (FFU) creates a vertical unidirectional flow at a wind speed of 0.45m/s ± 20%, ensuring that the core operation area reaches the ISO 5-level cleanliness standard. The specially designed non-angled structure can prevent microbial retention. The deep cooling fan system equipped in the freeze-drying machine can operate stably at an ultra-low temperature of -80℃, and is combined with precise pressure difference control to ensure the sublimation drying efficiency of the freeze-drying process. The three-level filtration exhaust system used in the biosafety laboratory uses a BIBO bag-in-bag-out design to achieve safe replacement of the high-efficiency filter, with a filtration efficiency of 99.9995% for 0.3μm particles. The powder conveying process in pharmaceuticals uses an oil-free screw fan, which has a completely sealed structure to avoid cross-contamination of drugs. The variable frequency control makes the conveying speed precise to ±0.1m/s. The isolation system of the vaccine production line integrates a HEPA filtering fan to maintain an internal positive pressure of 5-20Pa, and the real-time monitoring system can track 18 parameters such as particle count, temperature, and humidity. Modern pharmaceutical factories have introduced intelligent fan cluster control systems, which connect with the MES system through the OPC-UA protocol to achieve automatic adjustment of the air change rate in the cleanroom, reducing energy consumption by 40% compared to traditional systems. With the development of biopharmaceuticals, new magnetic levitation centrifugal fans have achieved vibration values of less than 0.5mm/s in the cell culture process, and their non-mechanical friction characteristics fully meet the requirements of aseptic production. In the future, pharmaceutical manufacturing will deeply integrate digital twin technology. The fan system can simulate and predict the airflow organization state of the cleanroom, providing a more intelligent environmental control solution for high-end preparations such as antibody drugs. The application of AI algorithms will enable breakthroughs in fault warning and energy efficiency optimization for fans.